Roman Hryshchenko was born on 17 January 1982 in the village of Katerynka, Pervomaisk district, Mykolaiv region, Ukraine. In 2005, he graduated from the Yaroslav the Wise National Law Academy of Ukraine in Kharkiv with a degree in law. From 2005 to 2007, he worked as an investigator at the Military Prosecutor's Office of the Mykolaiv Garrison of the Southern Region of Ukraine in Mykolaiv.

In 2010-2019, he worked in the military prosecutor's offices of the Mykolaiv, Kirovohrad, Kryvyi Rih, Kyiv and Kharkiv garrisons.

Head of Sumy Regional State Administration from 11 March 2020 to 5 November 2020.

Officer of the tactical level military command. Participant in hostilities in the ATO zone.

From the beginning of the Russian large-scale invasion, he served in the 112th separate brigade of the Territorial Defence Forces as a rifleman-operator, where he took part in the defence of Kyiv. On 4 March 2022, he was seconded to the city of Kharkiv and headed the new 127th separate brigade of the Territorial Defence Forces.

On 24 May 2022, he was awarded the Order of Bohdan Khmelnytskyi (III class) for personal courage and selfless actions in the defence of state sovereignty and territorial integrity of Ukraine, and loyalty to the military oath.

His call sign is "Uncle Roma".